Detailed view for TVAG_186530

Basic information

TDR Targets ID: 887517
Trichomonas vaginalis, DNA-directed RNA polymerase subunit rpb8, putative
Source Database / ID: 

pI: 4.8145 | Length (AA): 146 | MW (Da): 16743 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03870   RNA polymerase Rpb8

Gene Ontology

Mouse over links to read term descriptions.
GO:0006351   transcription, DNA-dependent  

Metabolic Pathways

Purine metabolism (KEGG)
Pyrimidine metabolism (KEGG)
Global map (KEGG)
RNA polymerase (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127936)

Species Accession Gene Product
Arabidopsis thaliana AT3G59600   RNA polymerase Rpb8
Arabidopsis thaliana AT1G54250   DNA-directed RNA polymerases II and V subunit 8A
Babesia bovis BBOV_IV005100   RNA polymerase subunit 8c, putative
Brugia malayi Bm1_26995   DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide
Candida albicans CaO19.6314   16-kDa RNA polymerase subunit
Candida albicans CaO19.13691   16-kDa RNA polymerase subunit
Caenorhabditis elegans CELE_F26F4.11   Protein RPB-8
Cryptosporidium hominis Chro.10257   RNA polymerase subunit 8c
Cryptosporidium parvum cgd1_2260   RNA polymerase II B8 subunit
Dictyostelium discoideum DDB_G0278039   RNA polymerase I core subunit
Drosophila melanogaster Dmel_CG11246   CG11246 gene product from transcript CG11246-RA
Echinococcus granulosus EgrG_000117600   dna directed rna polymerases i ii and iii
Entamoeba histolytica EHI_038570   RNA polymerase subunit Rpb8
Echinococcus multilocularis EmuJ_000117600   dna directed rna polymerases i ii and iii
Giardia lamblia GL50803_15144   RNA polymerase II subunit Rpb8
Homo sapiens ENSG00000163882   polymerase (RNA) II (DNA directed) polypeptide H
Leishmania braziliensis LbrM.28.0850   RNA polymerase B subunit RPB8, putative
Leishmania donovani LdBPK_280870.1   RNA polymerase B subunit RPB8, putative
Leishmania infantum LinJ.28.0870   RNA polymerase B subunit RPB8, putative
Leishmania major LmjF.28.0810   RNA polymerase B subunit RPB8, putative
Leishmania mexicana LmxM.28.0810   RNA polymerase B subunit RPB8, putative
Loa Loa (eye worm) LOAG_00799   DNA-directed RNA polymerase I
Mus musculus ENSMUSG00000021018   polymerase (RNA) II (DNA directed) polypeptide H
Mus musculus 102640226   DNA-directed RNA polymerases I, II, and III subunit RPABC3-like
Neospora caninum NCLIV_033350   UDP-glucose 4-epimerase Gal10, related
Oryza sativa 4341946   Os06g0697400
Oryza sativa 4334766   Os03g0845700
Plasmodium berghei PBANKA_1429500   DNA-directed RNA polymerases I, II, and III subunit RPABC3, putative
Plasmodium falciparum PF3D7_1213700   DNA-directed RNA polymerases I, II, and III subunit RPABC3, putative
Plasmodium knowlesi PKNH_1433200   DNA-directed RNA polymerases I, II, and III subunit RPABC3, putative
Plasmodium vivax PVX_123375   RNA polymerase subunit 8c, putative
Plasmodium yoelii PY02017   DNA-directed RNA polymerases i, ii, and iii 17.1 kDa polypeptide
Saccharomyces cerevisiae YOR224C   DNA-directed RNA polymerase core subunit RPB8
Schistosoma japonicum Sjp_0070380   ko:K03016 DNA-directed RNA polymerase II subunit H, putative
Schistosoma mansoni Smp_006850   DNA-directed rna polymerase subunit rpb8
Schmidtea mediterranea mk4.004862.04   Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3
Schmidtea mediterranea mk4.007396.00   Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3
Trypanosoma brucei gambiense Tbg972.11.9040   RNA polymerase B subunit RPB8, putative
Trypanosoma brucei Tb927.11.7930   RNA polymerase B subunit RPB8, putative
Trypanosoma cruzi TcCLB.506933.80   RNA polymerase B subunit RPB8, putative
Toxoplasma gondii TGME49_233720   DNA-directed RNA polymerase II RPBABC8
Theileria parva TP01_0233   RNA polymerase subunit, putative
Trichomonas vaginalis TVAG_186530   DNA-directed RNA polymerase subunit rpb8, putative

Essentiality

TVAG_186530 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.5790 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.5790 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.5790 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.5790 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F26F4.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_F26F4.11 Caenorhabditis elegans larval arrest wormbase
CELE_F26F4.11 Caenorhabditis elegans slow growth wormbase
CELE_F26F4.11 Caenorhabditis elegans sterile wormbase
YOR224C Saccharomyces cerevisiae inviable yeastgenome
TGME49_233720 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_186530 (Trichomonas vaginalis), DNA-directed RNA polymerase subunit rpb8, putative
Title for this comment
Comment